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Amlodipine has been safely administered with thiazide diuretics, beta-adrenoceptor blocking drugs, angiotensin-converting enzyme inhibitors, long-acting nitrate, sublingual glyceryl trinitrate, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycaemic agents.
Co-administration of Amlodipine with digoxin did not change serum digoxin levels or digoxin renal clearance in normal volunteers. Co-administration of cimetidine did not alter the pharmacokinetics of Amlodipine.
In healthy volunteers, co-administration of Amlodipine did not significantly alter the effect of warfarin on prothrombin time. The introduction of Amlodipine is not likely to result in the need for modification of an established warfarin agents.
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