Amlocor Dosage/Direction for Use

Adults: For both hypertension and angina, the recommended initial dose is 5 mg. Amlodipine orally once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response. Small, fragile or elderly patients & patients with hepatic insufficiency may be started on Amlodipine 2.5 mg once daily and this dose may be used when adding Amlodipine to other antihypertensive or antianginal therapy. Amlodipine can be administered with or without food.
Use in elderly: Although elderly patients may have higher plasma concentrations of Amlodipine than younger patients the terminal elimination half-lives in both are similar.
Amlodipine is similarly well-tolerated in elderly or younger patients. Therefore, the normal dosage of Amlodipine is recommended for elderly people.
Use in patients with renal impairment: Amlodipine is extensively metabolised to inactive metabolites with 10% of excreted drug in the urine. Changes in amlodipine plasma concentrations are not correlated with the degree of renal impairment; therefore, the normal dosage is recommended in patients with renal impairment. Amlodipine is not dialysable.
Use in patients with impaired hepatic function: The half-life of Amlodipine is prolonged in patients with impaired liver function. Amlodipine should therefore be administered with caution in such patients.