Amlodipine is generally well tolerated. The most commonly observed side effects are headache, oedema, fatigue, flushing and dizziness. Less common side effects include nausea, abdominal pain, somnolence and palpitations. Rare side effects include muscle cramps, frequency of micturition or nocturia, coughing, breathlessness, epistaxis, impotence, nervousness and conjunctivitis. No clinically significant pattern of laboratory test abnormalities related to Amlodipine has been observed.
Amlodipine has not been associated with any adverse effects or changes in plasma lipids. Amlodipine has been used safely in patients with well compensated congestive heart failure, peripheral vascular disease, chronic obstructive pulmonary disease, abnormal lipid profiles and diabetes mellitus.