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Lactic Acidosis: Lactic Acidosis is a rare, but serious metabolic complication that can occur due to metformin accumulation during treatment with Glimepiride + Metformin tablet. Because impaired hepatic function may significantly limit the ability to clear lactate, Glimepiride + Metformin tablet should be generally avoided in patients with clinical or laboratory evidence of hepatic disease. Patients should be cautioned against excessive alcohol intake, either acute or chronic, when taking Glimepiride + Metformin tablet, since alcohol potentiates the effects of metformin HCl on lactate metabolism.
Increased Risk of Cardiovascular Mortality: The administration of oral antidiabetic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin.
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