Amaramet Special Precautions

General Precautions: Patients should be informed that Glimepiride + Metformin tablet must be swallowed whole and not crushed or chewed and that the inactive ingredients may occasionally be eliminated in the feces as a soft mass that may resemble the original tablet.
Diabetes-Like Symptoms: Glimepiride + Metformin tablet should be prescribed only for patients diagnosed with diabetes. They should be distinguished from diabetes-like symptoms (renal diabetes, geriatric glucose metabolism disorder, thyroid malfunction) including glucose intolerance, positive urine glucose.
Alcohol Intake: Alcohol is known to potentiate the effect of metformin on lactate metabolism. Patients, therefore, should be warned against excessive alcohol intake, acute or chronic, while receiving Glimepiride + Metformin tablet.
Effects on ability to drive and use machines: Alertness and reactions may be impaired due to hypoglycemia or hyperglycemia, especially when beginning or after altering treatment or when Glimepiride + Metformin is not taken regularly.
This may affect the ability to drive or to operate machinery.
Patients should be advised to drive a car or operate machinery with caution.
Use in Pregnancy & Lactation: See Use in Pregnancy & Lactation section for further information.
Use in Children: Safety and effectiveness in pediatric patients have not been established.
Use in the Elderly: Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and should be based on careful and regular monitoring of renal function. Metformin is known to be substantially excreted by the kidney and the risk of serious adverse reactions to metformin is greater in patients with impaired renal function. It should only be used in patients with normal renal function.