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Use in Pregnancy: Glimepiride + Metformin must not be taken by pregnant or possibly pregnant women. In animal study, teratogenicity was reported and lactic acidosis is easy to occur. Pregnant patient or the patient planning a pregnancy must inform their physician about their diabetes and they should not be treated with metformin but insulin should be used to maintain blood glucose levels.
Use in Lactation: Studies in lactating rats show that metformin and glimepiride are excreted into milk. So, Glimepiride + Metformin must not be taken by breastfeeding women. If necessary, the patient must change over to insulin or must stop breastfeeding.
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