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Known hypersensitivity to any of the excipients of Glimepiride + Metformin tablet, sulfonylureas, sulfonamides or biguanide.
Insulin dependent (type 1) diabetes (e.g., diabetics with a history of ketonemia), diabetic ketonemia, diabetic coma or precoma.
Patients with severe hepatic dysfunction or hemodialysis. In case of severe hepatic or renal function disorders, a change over to insulin is required to achieve adequate control of blood glucose.
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