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Alprazolam is contraindicated in patients with known hypersensitivity to this drug or other benzodiazepines.
Alprazolam may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma.
Alprazolam is contraindicated with ketoconazole and itraconazole, since these medications significantly impair the oxidative metabolism mediated by cytochrome P450 3A (CYP3A).
It is also contraindicated in those with severe hepatic impairment.
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