Some patients may experience a paradoxical excitation which may lead to hostility, aggression, and disinhibition. Jaundice, blood disorders, and hypersensitivity reactions have been reported rarely. Respiratory depression and hypotension occasionally occur with high dosage and parenteral use.
Raised liver enzyme values have occurred.
Overdosage can produce CNS depression and coma or paradoxical excitation. However, fatalities are rare when taken alone.
Use of alprazolam in the first trimester of pregnancy has occasionally been associated with congenital malformations in the infant but no clear relationship has been established.
Use of alprazolam in late pregnancy has been associated with intoxication of the neonate. Alprazolam on prolonged use may lead to habituation and dependence.
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