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Management of acute poisoning with non-steroidal anti-inflammatory agents consists essentially of supportive and symptomatic measures. There is no typical clinical picture resulting from an overdosage of diclofenac.
The therapeutic measures to be taken in cases of overdosage by means of gastric lavage and treatment with activated charcoal.
Supportive and symptomatic treatment should be given for complications such as hypotension, renal failure, convulsions, gastrointestinal irritation, and respiratory depression.
Specific therapies such as forced diuresis, dialysis, or haemoperfusion are probably of no help in eliminating non-steroidal anti-inflammatory agents, because of their high protein-binding rate and extensive metabolism.
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