Votan SR Drug Interactions

When given together with preparations containing lithium or digoxin, diclofenac may raise their plasma concentrations, but no clinical signs of overdosage in such cases have yet been encountered.
Various non-steroidal anti-inflammatory agents are liable to inhibit the activity of diuretics. Concomitant administration of systemic non-steroidal anti-inflammatory agents or glucocorticoids may increase the occurrence of side effects.
Clinical investigations would appear to indicate that Votan has no influence on the effect of oral anticoagulants. As a precaution, however, it is recommended that, when giving concomitant treatment with Votan and anticoagulants, laboratory tests should be performed in order to check that the desired response to the anticoagulants is being maintained.
As with other non-steroidal anti-inflammatory agents, diclofenac in a high dose (200 mg) can temporarily inhibit platelet aggregation.
Clinical studies have shown that Votan can be given together with oral antidiabetic agents without influencing their clinical effect.
Caution should be exercised when non-steroidal anti-inflammatory drugs are administered less than 24 hours before or after treatment with methotrexate, since the blood concentration of methotrexate may rise and the toxicity of this substance may be increased.