Prostimix

Propylthiouracil inhibits thyroid hormone synthesis in the thyroid gland by preventing iodination of tyrosine inside of thyroglobulin. This substance also inhibits T4 (tyrosine) to T3 conversion in peripheral tissues.

Treatment of hyperthyroidism for relieve clinical symptoms and to prepare for surgery. May be used in combination with radioactive iodine to accelerate clinical improvement while awaiting the therapeutic effects of radioactive iodine.

Adult An initial dose of 300-600 mg daily in divided doses, with 6-8 hours interval. Doses may increase to 12 g daily in initial control. Administered until patients reach euthyroid condition. Maintenance dose 100-300 mg in 3 divided doses. Thyrotoxic crisis 600-1200 mg in divided doses.
Children >10 years Initial dose 50-300 mg daily in divided doses, with 6-8 hours interval. Maintenance dose 100-300 mg daily in 2 divided doses with 2 hours intervals.
Children 6-10 years Initial dose 50-150 mg daily in divided doses, with 6-8 hours interval.
Neonatal Thyrotoxicosis 10 mg / kg BW.

Propylthiouracil is contraindicated in patients who are hypersensitive to this drug. Small amounts of propylthiouracil are excreted in breast milk and it is possible to cause hyperthyroidism in the baby, especially if the mother is receiving high doses. Pregnancy, especially in the third trimester can cause infant death. Congenital abnormalities. Hypothyroidism.

Propylthiouracil crosses the placenta and can cause disruption of the fetus when given to pregnant women, causing goiter and hyperthyroidism in the fetus. Therefore, dose adjustment is needed when used during pregnancy to regulate hyperthyroidism and stop therapy in the third trimester of pregnancy.
Patients receiving Propylthiouracil should be monitored and advised to contact a doctor immediately if symptoms of pain appear such as headache, fever, sore throat, skin damage, feeling unwell because they are symptoms of agranulocytosis.
Hypersensitivity reactions may occur in some patients.
Beware of bone marrow depression, impaired liver function in asthmatics. Discontinue administration if there is a polyserositis syndrome that looks-like lupus erythematosus. Patients who have had success with antithyroid treatment at risk of hyperthyroidism, need to check regularly every year.

Propylthiouracil rarely causes side effects, the most common of which are pruritus and rash which sometimes go away without any cure.
Other symptoms that rarely arise are agranulocytosis, pain and stiffness of joints, especially in the hands and wrists. But this usually occurs at high doses.
Nausea, headache, stomach cramps, dizziness, drowsiness, fever, chills, granulocytopenia, paresthesia.

Propylthiouracil may increase the effect of anticoagulants such as coumarin and heparin, the dose adjustment is needed for co-administration with these substances. Propylthiouracil with KI (Potassium iodide) or Lithium may amplify the effect hyperthyroidism and goitrogenic effects.
Concomitant administration of hepatotoxic drugs may increase the risk of hepatotoxicity.

Store in the temperature 30°C.

Antithyroid Agents

H03BA02 - propylthiouracil ; Belongs to the class of thiouracils. Used in the management of thyroid diseases.

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