Although there are no evidence of rebound phenomenon of gabapentin, the abrupt withdrawal of anticonvulsant agents in epileptic patients may trigger status epilepticus. If there is a dose reduction, discontinuation or substitution with an alternative anticonvulsant should be done gradually over a minimum of 1 week.
Gabapentin is generally not considered effective in the treatment of seizures and may aggravate seizures in some patients. Therefore, gabapentin should be taken carefully in patients who experienced mixed seizure, including abscence seizures.
Due to reports of false-positive result with the Ames N-Multistix sg dipstick test for urine protein when Gabapentin is added to other antiepileptic medications, the more specific sulfosalicylic acid precipitation procedure is recommended for detecting the presence of urine protein.
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