Adult and children >12 years old: Gabapentin is administered orally with or without meals. In clinically controlled study, the effective dose are 900-1,800 mg daily. The titration to reach the effective dose can progress rapidly and may be achieved within a few days with a 300 mg dose once daily on the first day: 300 mg twice daily on the second day: 300 mg 3 times daily on the third day. After that, doses may be increased to 1,200 mg daily in 3 divided doses, and if necessary, titration can continue using 300 mg/day increments given in 3 divided doses until a maximum of 2,400 mg/day. The maximum period between doses when administering three times a day should not exceed 12 hours. If Gabapentin is discontinued and/or an alternative anticonvulsant is added, this should be performed gradually for at least of 1 week.
Patients with impaired kidney function or undergoing hemodialysis: Adjustment dose is recommended (see table).
Unlike other drugs in the same group, plasma level monitoring is not required for optimal therapeutic effects of Gabapentin. Furthermore, Gabapentin can be used in combination with other anticonvulsant medications without affecting the plasma or serum levels of these drugs. If Gabapentin treatment is stopped and/or if another anticonvulsant is added, monitoring should be carried out gradually for at least 1 week. (See table.)
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Administration: With or without food.