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Coadministration with potent inhibitors of CYP3A4 activity blocks the metabolism of silodosin. This may result in elevated plasma drug concentrations. (See Table 9.)
Click on icon to see table/diagram/imageNon-Japanese data: Ketoconazole (oral preparation not marketed in Japan) coadministration: When 16 healthy male volunteers (non-Japanese) who were receiving 200 mg of ketoconazole (p.o.) once daily for 4 days were coadministered a single 4 mg dose of silodosin capsule (p.o.) on day 2, Cmax and AUC0-∞ of silodosin increased 3.7- and 2.9-fold, respectively, compared to when silodosin alone was administered.
Digoxin coadministration: When silodosin capsule (4 mg, twice daily) was coadministered orally with digoxin (0.25 mg, once daily) for 8 days to 16 healthy male volunteers (non-Japanese), it was confirmed that silodosin capsule has no effect on the pharmacokinetic profile of digoxin.
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