Tazilsun Dosage/Direction for Use

Piperacillin/tazobactam may be given by slow intravenous infusion (over 20-30 minutes) or by slow intravenous injection (over at least 3-5 minutes). Piperacillin/tazobactam should be administered separately from any other antibiotic such as an aminoglycoside. The mixing of piperacillin/tazobactam with aminoglycosides in vitro can result in substantial inactivation of the aminoglycoside. Piperacillin/tazobactam and the aminoglycoside should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated (see Interactions).
Adults and children 12 years and older: The usual intravenous dosage for adults and children with normal renal function is 4 g piperacillin/0.5 g tazobactam given every eight hours. The total daily dose depends on the severity and localization of the infection and can vary from 2 g piperacillin/0.25 g tazobactam to 4 g piperacillin/0.5 g tazobactam administered every six, eight or twelve hours.
Duration of Therapy: The usual duration of piperacillin/tazobactam treatment is from seven to ten days. However, the recommended duration of piperacillin/tazobactam treatment of nosocomial pneumonia is 7 to 14 days. In all conditions, the duration of therapy should be guided by the severity of the infection and the patient's clinical and bacteriological progress.
Renal Insufficiency: In patients with renal insufficiency (Creatinine Clearance ≤40 mL/min), or patients on hemodialysis, the intravenous dose and dosing interval of this product (piperacillin and tazobactam for injection) should be adjusted to the degree of actual renal function impairment. In patients with nosocomial pneumonia receiving concomitant aminoglycoside therapy, the aminoglycoside dosage should be adjusted according to the recommendations of the manufacturer. The recommended daily doses of this product for patients with renal insufficiency are as follows: See Table 4.

Click on icon to see table/diagram/image

For patients on hemodialysis, the maximum dose is 2.25 g every twelve hours for all indications other than nosocomial pneumonia and 2.25 g every eight hours for nosocomial pneumonia. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g piperacillin/tazobactam should be administered following each dialysis period on hemodialysis days. No additional dosage of this product is necessary for CAPD patients.
Pediatric Patients: For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended dosage of this product is 100 mg piperacillin/12.5 mg tazobactam per kilogram of body weight, every 8 hours. For pediatric patients between 2 months and 9 months of age, the recommended dosage of this product based on pharmacokinetic modeling, is 80 mg piperacillin/10 mg tazobactam per kilogram of body weight, every 8 hours (see Use in Children under Precautions and Pharmacology: Pharmacokinetics under Actions). Pediatric patients weighing over 40 kg and with normal renal function should receive the adult dose. There are no dosage recommendations for this product in pediatric patients with impaired renal function.