IV Slow infusion over 20-30 min or slow inj over at least 3-5 min.
Adult & childn ≥12 yr w/ normal renal function 4 g piperacillin/0.5 g tazobactam every 8 hr for 7-10 days.
Nosocomial pneumonia Max dose: 2.25 g every 8 hr for 7-14 days in patient on hemodialysis.
Renal insufficiency w/ CrCl 20-40 mL/min 2.25 g every 6 hr,
<20 mL/min 2.25 g every 8 hr.
Patient on hemodialysis Max dose: 2.25 g every 12 hr w/ additional dose of 0.75 g piperacillin/tazobactam following each dialysis period.
Appendicitis &/or peritonitis Ped patient weighing >40 kg w/ normal renal function Adult dose,
≥9 mth weighing up to 40 kg w/ normal renal function 100 mg piperacillin/12.5 mg tazobactam/kg every 8 hr,
2-8 mth 80 mg piperacillin/10 mg tazobactam/kg every 8 hr.
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