Tazilsun Caution For Usage

Directions for Reconstitution and Dilution for Use: Intravenous Administration: For conventional vials, reconstitute this drug per gram of piperacillin with 5 mL of a compatible reconstitution diluent from the list provided as follows. Reconstitute each vial with the volume of diluent shown in the following table, using one of the compatible diluents. Swirl until dissolved. (See Table 7.)

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The reconstituted solution should be used immediately. Discard any unused portion after 24 hours if stored at room temperature (20°C to 25°C), or after 48 hours if stored at refrigerated temperature (2°C to 8°C).
Compatible Reconstitution Diluents: 0.9% Sodium Chloride for Injection; Sterile Water for Injection**; Dextrose 5%; Bacteriostatic Saline/Parabens; Bacteriostatic Water/Parabens; Bacteriostatic Saline/Benzyl Alcohol; Bacteriostatic Water/Benzyl Alcohol.
Reconstituted solution should be further diluted (recommended volume per dose of 50 mL to 150 mL) in a compatible intravenous solution listed as follows. Administer by infusion over a period of at least 30 minutes. During the infusion it is desirable to discontinue the primary infusion solution.
Compatible Intravenous Solutions: 0.9% Sodium Chloride for Injection; Sterile Water for Injection**; Dextrose 5%; Dextran 6% in Saline.
** Maximum recommended volume per dose of Sterile Water for Injection is 50 mL.
ADD-Vantage System Admixtures: Dextrose 5% in Water (50 or 100 mL); 0.9% Sodium Chloride (50 or 100 mL).
For ADD-Vantage vials reconstitution directions, see Instructions For Use sheet provided in the box. Lactated Ringer's Solution is compatible only with reformulated piperacillin/tazobactam containing EDTA.
Piperacillin/tazobactam should not be added to blood products or albumin hydrolysates.
Piperacillin/tazobactam should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established.
Piperacillin/tazobactam is not chemically stable in solutions that contain only sodium bicarbonate.
Piperacillin/tazobactam can be used in ambulatory intravenous infusion pumps.
Stability of This Product Following Reconstitution: This product is stable in glass and plastic containers (plastic syringes, I.V. bags and tubing) when used with compatible diluents.
The reconstituted solution should be used immediately. Discard any unused portion after 24 hours if stored at room temperature (20°C to 25°C), or after 48 hours if stored at refrigerated temperature (2°C to 8°C). The vial should not be frozen after reconstitution.
Stability studies in the I.V. bags have demonstrated chemical stability (potency, pH of reconstituted solution, and clarity of solution) for up to 24 hours at room temperature and up to one week at refrigerated temperature. This product contains no preservatives. Appropriate consideration of aseptic technique should be used and were aseptically transferred into the medication reservoir (I.V. bags or cartridge). The reservoir was fitted to a preprogrammed ambulatory intravenous infusion pump per the manufacturer's instructions. Stability of this product is not affected when administered using an ambulatory intravenous infusion pump. Stability studies with the admixed ADD-Vantage system have demonstrated chemical stability (potency, pH and clarity) through 24 hours at room temperature. (Note: The admixed ADD-Vantage should not be refrigerated or frozen after reconstitution.) Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.