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Pharmacology: Pharmacodynamics: Calcium polystyrene sulfonate, the calcium salt of sulfonate styrene polymer, is a cation-exchange resin that exchanges calcium ions for potassium ion and other cations in the gastrointestinal tract. It is used to enhance potassium excretion in the treatment of hyperkalaemia and may be preferred to the sodium resin in patients who cannot tolerate an increase in their sodium load.
Pharmacokinetics: After administration of calcium polystyrene sulfonate via oral or rectal route, calcium ion of calcium polystyrene sulfonate is exchanged for the potassium ion in the intestinal tract, particularly around the colon, and the drug is excreted as unchanged polystyrene sulfonate resin into the feces without digestion and absorption. In consequence, potassium in the intestinal tracts excreted outside the body.
