Kinelene Drug Interactions

Calcium ions are released from the resin in the gastrointestinal tract and this may reduce the absorption of tetracycline given by mouth.
Concomitant administration of calcium salts with bisphosphonates (e.g. alendronate, etidronate, ibandronate, risedronate) may reduce absorption of the bisphosphonate from GI tract. To minimize this effect, calcium salts should be administrated at least 30 minutes after alendronate or risedronate, at least 60 minutes after ibandronate, and not within 2 hours of etidronate administration.
The inotropic and toxic effects of cardiac glycosides and calcium are synergistic and arrhythmias may occur if these drugs are given together.
Concomitant administration of calcium salts and oral iron preparations may result in reduced absorption of iron. Patients should be advised to take the drugs at different times.
Concomitant administration of calcium salts and some fluoroquinolones (e.g. ciprofloxacin) may reduce oral bioavailability of the fluoroquinolones.