Hofbic 7.5 Special Precautions

Not to be used in patients with hypersensitivity to Meloxicam or any ingredient in the formulation or patient with history of urticaria, angioedema, bronchospasm, severe rhinitis or shock precipitated by aspirin or NSAIDs.
Patients whose renal blood flow and blood volume decreased, administration of the NSAIDs may enhance the renal dysfunction because NSAIDs inhibit the synthesis of renal prostaglandin, which play a supportive role in the maintenance of renal perfusion.
The dose of HOFBIC 7.5 in patients with end-stage renal failure on hemodialysis should not be higher than 7.5 mg. No dose reduction is required in patients with mild or moderate renal impairment (i.e. in patients with a creatinine clearance of greater than 25 ml/min).
Not to be used in dengue fever patient.
Risk of GI ulceration, bleeding. Meloxicam can cause serious gastrointestinal adverse events including inflammation, bleeding, ulceration and perforation of the stomach and intestine.
An increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction and stroke.
Patients who are more likely to be suffering from impaired renal, hepatic or cardiac function include frail or debilitated patients may tolerate side effects less well and such patients should be carefully supervised and monitored.
May cause cardiac failure or hypertension from the induction of sodium potassium, water retention and interference with natriuretic effects of diuretic.
Meloxicam inhibits platelet aggregation and has been shown to prolong bleeding time should be avoided in some patient who may be adversely affected by alteration in platelet function.
If these symptoms occur such as fever, eczema, blister, the extraction of skin and other membranes such as in cavity, e.g. nose, genital and conjunctivitis. Discontinue this drug and consult with a physician because Stevens-Johnson syndrome may occur.
At first appearance of skin rash, fever or other sign of hypersensitivity, discontinue immediately and consult with physician.
Use in Pregnancy & Lactation: See USE IN PREGNANCY & LACTATION section for further information.
Use in the Elderly: The consequences of such events are generally more serious in the elderly: Gastrointestinal bleeding, ulceration or perforation, potentially fatal, can occur at any time during treatment.
Monitor carefully in patients reporting mucocutaneous.
Beware use in hypertensive patient or elderly patient.