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Pharmacology: Pharmacodynamics: HOFBIC, an oxicam derivative, is an NSAID which is a selective inhibitor of cyclo-oxygenase-2 (COX-2), more than COX-1, which results in decreased prostaglandin precursors associated with anti-inflammatory activity.
Pharmacokinetics: HOFBIC is well absorbed following oral administration. It is 99.5% bound to plasma proteins. HOFBIC has a plasma elimination half-life of approximately 20 hours.
It is extensively metabolized via cytochrome P450 (CYP 2C9 and CYP 3A4) mainly by oxidation and excreted in similar amounts in the urine and in the feces; less than 3% of a dose is excreted unchanged. The volume of distribution is increased in severe renal failure.
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