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Film-coated tablet: In the case of severe renal insufficiency, desloratadine should be used with caution (see Pharmacology: Pharmacokinetics under Actions).
Desloratadine should be administered with caution in patients with medical or familial history of seizures, and mainly young children (see Adverse Reactions), being more susceptible to develop new seizures under desloratadine treatment. Healthcare providers may consider discontinuing desloratadine in patients who experience a seizure while on treatment.
Syrup: Efficacy and safety of DESTA SYRUP in children under 6 months of age have not been established.
This medication may cause drowsiness in some patients. Individual response should be determined that it does not cause drowsiness before driving, operating machines or working in areas with risk of falling.
Be careful in patients with renal disease. In the case of severe renal insufficiency (GFR <30 ml/min), DESTA SYRUP should be used as alternate day dosage until the physicians can determine the individual patient's response.
Serum levels of this medication may be increased when using with macrolides antimicrobials such as erythromycin or imidazole antifungal such as ketoconazole. No clinically relevant changes in desloratadine plasma concentrations were observed in multiple-dose ketoconazole and erythromycin interaction trials.
Desloratadine should be administered with caution in patients with a medical or family history of seizures. In particular, young children may be more susceptible to developing new seizures under desloratadine treatment. Healthcare providers may consider discontinuing desloratadine in patients who experience a seizure while on treatment.
Effects on ability to drive and use machines: Film-coated tablet: Desloratadine has no or negligible influence on the ability to drive and use machines. Patients should be informed that most people do not experience drowsiness. Nevertheless, as there is individual variation in response to all medicinal products, it is recommended that patients are advised not to engage in activities requiring mental alertness, such as driving a car or using machines, until they have established their own response to the medicinal product.
Syrup: No effects on the ability to drive and use machines have been observed (see Pharmacology: Pharmacodynamics under Actions).
