Zicef Dosage/Direction for Use

Cefuroxime sodium may be given by deep intramuscular injection, by slow intravenous injection over 3 to 5 minutes, or by intravenous infusion.
Adult dose: By injection the usual dose is 750 mg of cefuroxime every 8 hours but in more severe infections 1.5 g may be given intravenously every 8, or in some cases every 6 hours.
Infants and children: It can be given 30 to 60 mg/kg daily, increased to 100 mg/kg daily if necessary, given in 3 or 4 divided doses. Neonates may be given similar total daily doses but in 2 or 3 divided doses.
Adults with pneumonia or with acute exacerbations of chronic bronchitis: May respond to sequential therapy with parenteral cefuroxime 1.5 g twice daily or 750 mg twice daily respectively, followed by oral cefuroxime 500 mg twice daily in each case.
For the treatment of meningitis due to sensitive strains of bacteria: Cefuroxime is given intravenously in adult doses of 3 g every 8 hours. Infants and children are given 200 to 240 mg/kg daily intravenously in 3 or 4 divided doses, which may be decreased to 100 mg/kg daily after 3 days or when there is clinical improvement. For neonates, a dose of 100 mg/kg daily, decreased to 50 mg/kg daily when indicated, may be used.
In the treatment of gonorrhea: A single dose of 1.5 g by intramuscular injection, divided between 2 injection sites, has been used.
For surgical infection prophylaxis: The usual dose is 1.5 g of cefuroxime intravenously before the procedure; this may be supplemented by 750 mg intramuscularly every 8 hours for up to 24 to 48 hours depending upon the procedure.
Administration in renal impairment: Parenteral doses of cefuroxime may need to be reduced in renal impairment. Licensed product information suggests the following doses based on creatinine clearance (CC): CC 10 to 20 mL/minute: 750 mg twice daily; CC less than 10 mL/minute: 750 mg once daily.
Patients undergoing haemodialysis should receive an additional 750-mg dose following each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg twice daily.