IM/IV May be given by deep IM inj, slow IV inj over 3-5 min or IV infusion.
Adult 750 mg every 8 hr.
More severe infections 1.5 g IV every 8 hr, or in some cases every 6 hr.
Infant & childn 30-60 mg/kg daily, increased to 100 mg/kg daily if necessary, in 3 or 4 divided doses.
Neonates Similar total daily doses but in 2 or 3 divided doses.
Adult w/ pneumonia or w/ acute exacerbations of chronic bronchitis 1.5 g bid or 750 mg bid respectively, followed by oral cefuroxime 500 mg bid in each case.
Meningitis due to sensitive strains of bacteria Adult 3 g IV every 8 hr.
Infant & childn 200-240 mg/kg daily IV in 3 or 4 divided doses, may be decreased to 100 mg/kg daily after 3 days or when there is clinical improvement.
Neonates 100 mg/kg daily, decreased to 50 mg/kg daily when indicated, may be used.
Gonorrhea Single dose of 1.5 g by IM inj, divided between 2 inj sites.
Surgical infection prophylaxis 1.5 g IV before the procedure; may be supplemented by 750 mg IM every 8 hr for up to 24-48 hr depending upon the procedure.
Renal impairment CrCl 10-20 mL/min 750 mg bid,
<10 mL/min 750 mg once daily.
Patient undergoing haemodialysis Additional 750-mg dose following each dialysis.
Patient undergoing continuous peritoneal dialysis 750 mg bid.
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