Zicef Adverse Reactions

Hypersensitivity reactions: Including skin rashes (maculopapular and urticarial), interstitial nephritis, drug fever and, very rarely, anaphylaxis. As with any antibiotic, prolonged use may lead to overgrowth of nonsusceptible organisms, eg, Candida. As with other cephalosporins, there have been rare reports of erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis.
Gastro-intestinal disturbance: Including, very rarely, pseudomembranous colitis, which has been reported with most broad spectrum antibiotics.
Hematological: A decrease in hemoglobin concentration, eosinophilia, leucopenia and neutropenia has been observed. Positive Coombs' tests have been reported. As with other cephalosporins, thrombocytopenia has been reported rarely.
Hepatic: Transient rises in liver enzymes or serum bilirubin have been observed, particularly in patients with pre-existing liver disease, but there is no evidence of hepatic involvement.
Renal: There may be some variation in the results of biochemical tests of renal function, but these results do not appear to be of clinical significance.
Other: Transient pain may be experienced at the site of intramuscular injection. Occasionally thrombophlebitis may occur at the site of intravenous injection. A burning sensation may be observed after intravenous injection. Mild to moderate hearing loss has been reported in some children treated for meningitis. Dizziness and headache has been reported in patients receiving cefuroxime.