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Warfarin should not be given to patients who are hemorrhaging. In general, it should not be given to patients at serious risk of hemorrhage, although it has been used with very careful control; patients at risk include those with hemorrhagic blood disorders, peptic ulcer disease, severe wounds (including surgical wounds), cerebrovascular disorders, and bacterial endocarditis.
Many factors may affect anticoagulant control with Warfarin. These include vitamin K status, thyroid status, renal function, bioavailability differences between Warfarin preparations, factors affecting absorption of Warfarin, and drug interactions.
