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Tranexamic acid: There is no known cause of overdosage. Symptoms of overdosage may be nausea, vomiting, orthostatic symptoms and/or hypotension.
Mefenamic acid: Mefenamic acid has a marked tendency to induce tonic clonic (grand mal) convulsions in overdosage. Dyskinesia, acute renal failure and coma have been reported. Overdose has led to fatalities. Treatment is symptomatic and supportive. Following accidental overdosage, the stomach should be emptied by inducing emesis or gastric lavage followed by administration of activated charcoal. Vital functions should be monitored and supported. Haemodialysis is of little value since mefenamic acid and its metabolites are firmly bound to plasma proteins.
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