Tranamic Adverse Reactions

Tranexamic acid: Gastrointestinal disturbances: Nausea, vomiting, diarrhea, cramps.
Cardiovascular hypotension: Hypotension has been observed especially after rapid I.V. administration. However, this has not been reported with oral administration.
Other: Transient disturbances in colour vision associated with its use.
Musculoskeletal: Malaise, weakness, fatigue, elevated serum enzymes such as creatinine phosphokinase, rhabdomyolysis associated with myoglobinuria and renal failure have been reported.
CNS: Dizziness, tinnitus, headache, delirium, auditory, visual and kinesthetic hallucinations.
Miscellaneous: Conjunctival suffusion, nasal stuffiness, skin rash, reversible acute renal failure, thrombophlebitis.
Worldwide postmarketing report thromboembolic events (e.g. deep vein thrombosis, pulmonary embolism, cerebral thrombosis, acute renal cortical necrosis and central retinal artery and vein obstruction) have been rarely reported in patients receiving tranexamic acid.
Mefenamic acid: The most frequently reported adverse experiences: Gastrointestinal: Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal), vomiting, abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headache, increased bleeding time, pruritus, rash, tinnitus.
Additional adverse experiences reported occasionally: Body as a Whole: Fever, infection, sepsis.
Cardiovascular System: Congestive heart failure, hypertension, tachycardia, syncope.
Digestive System: Dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice.
Hemic and Lymphatic System: Ecchymosis, eosinophilia, leucopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia.
Metabolic and Nutritional: Weight changes.
Nervous System: Anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo.
Respiratory System: Asthma, dyspnea.
Skin and Appendages: Alopecia, photosensitivity, pruritus, sweat.
Special Senses: Blurred vision.
Urogenital System: Cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure.
Other adverse reactions, which occur rarely: Body as whole: Anaphylactoid reactions, appetite changes, death.
Cardiovascular System: Arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis.
Digestive System: Eructation, liver failure, pancreatitis.
Hemic and Lymphatic System: Agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia.
Metabolic and Nutritional: Hyperglycemia.
Nervous System: Convulsions, coma, hallucinations, meningitis.
Respiratory: Respiratory depression, pneumonia.
Skin and Appendages: Angioedema, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria.
Special Senses: Conjunctivitis, hearing impairment.