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Tranexamic acid is contraindicated in: Acquired defective colour vision: prohibits measuring one endpoint of toxicity.
Subarachnoid haemorrhage: Cerebral edema and cerebral infarction may be caused by tranexamic acid in patients with subarachnoid hemorrhage.
Active intravascular clotting.
Mefenamic acid: Contraindicated in patients with known hypersensitivity. Mefenamic acid should not be given to patients who have experienced asthma, urticaria or allergy-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported.
Other contraindications: Active ulceration or chronic inflammation of either the upper or lower gastrointestinal tract, renal disease with impaired renal or hepatic function and epileptics. Safety in pregnancy and lactation has not yet been established.
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