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Hypotension: Losartan potassium can cause symptomatic hypotension. Symptomatic hypotension is most likely to occur in patients who have been volume and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. Volume and/or salt depletion should be corrected before initiating therapy with Losartan potassium and Amlodipine besilate combination.
Hepatic failure: Rarely, angiotensin receptor inhibitors have been associated with a syndrome that starts with cholestatic jaundice and progresses to fulminant hepatic necrosis and (sometimes) death. The mechanism of this syndrome is not understood. Patients receiving this combination who developed jaundice or marked elevations of hepatic enzymes should discontinue the therapy and receive appropriate medical follow-up.
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