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Impaired Liver Function: Losartan potassium and Amlodipine besilate combination should be given with caution in patients with impaired hepatic function since the half-life of amlodipine is prolonged in patients with impaired liver function.
Impaired Renal Patients: As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals. In patients with severe congestive heart failure whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with angiotensin receptor blocker may be associated with oliguria and/or progressive azotemia and (rarely) with acute renal/failure and/or death.
Use in Children: The use of this product is not currently recommended for children and adolescents of less than 18 years of age.
