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Anticoagulants (Oral): The activity of anticoagulants may be potentiated by anti-vitamin K activity attributed to thiamazole.
β-Adrenergic Blocking Agents: Hyperthyroidism may cause an increased clearance of β-blockers with a high extraction ratio. A dose reduction of β-adrenergic blocking agents may be needed when a hyperthyroid patient becomes euthyroid.
Digitalis Glycosides: Serum digitalis levels may be increased when hyperthyroid patients on a stable digitalis glycoside regimen become euthyroid; a reduced dosage of digitalis glycosides may be required.
Theophylline: Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced dose of theophylline may be needed.
