Treatment of hyperthyroidism. May be used to ameliorate hyperthyroidism in prep for subtotal thyroidectomy or radioactive iodine therapy. Used when thyroidectomy is contraindicated or not advisable.
AdultMild hyperthyroidism Initially 15 mg daily. Moderately severe hyperthyroidism Initially 30-40 mg daily. Severe hyperthyroidism Initially 60 mg daily. Maintenance: 5-15 mg daily. All doses to be given in 3 equally divided doses at approx 8-hr intervals.
Long-term therapy may lead to remission of the disease. Discontinue use in the presence of agranulocytosis (symptoms include fever, sore throat, skin eruptions, headache or general malaise), aplastic anemia (pancytopenia), hepatitis, exfoliative dermatitis; hepatic transaminase >3 times ULN. Monitor prothrombin time especially before surgical procedures; bone marrow, liver & thyroid function periodically. Concomitant use w/ drugs known to cause agranulocytosis. Pregnancy.
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