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Pharmacology: Pharmacodynamics: Isoxsuprine hydrochloride is a beta2-adrenoceptor agonist that causes vasodilation by direct relaxation of vascular smooth muscle. Its beta2-adrenergic effects, however, are not essential to its vasodilating effect. Isoxsuprine decreases peripheral vascular resistance; blood pressure may be decreased by parental administration or large oral doses of isoxsuprine. Isoxsuprine may also have positive inotropic and chronotropic effects on the heart and may increase cardiac output.
Isoxsuprine also relaxes uterine smooth muscle and is valuable in arresting contractions in treated abortion and premature labor.
Mechanism of Action: Isoxsuprine is a vasodilator which also stimulate beta-adrenergic receptors. It causes direct relaxation of vascular and uterine smooth muscles and its vasodilation action is greater on the arteries supplying skeletal muscles than on those supplying skin. Isoxsuprine also produces positive inotropic and chronotropic effect.
Pharmacokinetics: Isoxsuprine hydrochloride is well absorbed in the gastrointestinal tract. The peak plasma concentration occurs about 1 hour after oral administration. The plasma half-life has been reported to be 1.5 hours. Isoxsuprine is excreted primary in the urine mainly as conjugates.
