Senokot

STANDARDIZED SENNA CONCENTRATE (SENOKOT) tablet is a natural vegetable laxatives derived from the senna plant that has been standardized for predictable results. The active components responsible for its laxative effect in STANDARDIZED SENNA CONCENTRATE (SENOKOT) are senna glycosides or sennosides.
Glycosides are converted into aglycones through the enzymatic action of colonic bacteria, which induce colonic peristalsis and bowel evacuation. This action is virtually colon-specific, since these compounds have little or no action in the stomach and small intestine.
Each tablet contains 187 mg Standardized Senna Concentrate equivalent to 8.77 mg Sennosides A and B or 374 mg Standardized Senna Concentrate equivalent to 17.54 mg Sennosides A and B.

Used as a natural laxative for the relief of constipation.

See table.

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Take preferably at bedtime. Bowel movement generally occurs within 6 to 12 hours following ingestion. The correct dose of the sennosides-containing laxatives is the smallest required to produce a comfortable bowel movement and varies between individuals.
Dosage can be adjusted to meet individual requirements. If comfortable bowel movement is not achieved by the second day, increase recommended dose by one tablet (up to maximum dosage) or decrease until the most effective dose is established or as prescribed by the doctor.
Missed Dose: Follow dosing instructions. If a dose is missed, take it as soon as remembered. If it is near the next dose, skip the missed dose and resume the usual dosing schedule. Do not double-up the dose to catch-up.

Signs & Symptoms: The major symptoms of overdose/abuse with any stimulant laxative including those containing senna are griping pain and severe diarrhea, leading to excessive water loss (dehydration) and possible electrolyte imbalance.
Treatment should be supportive with generous amounts of fluid. Electrolytes, especially potassium, should be monitored. This is especially important in the elderly.
In case of accidental overdose, please consult the doctor.

Sennosides-containing products are contraindicated in patients with known hypersensitivity to sennosides, or in patients with an acute surgical abdomen, abdominal pain of unknown origin, appendicitis, intestinal obstruction, and stenosis, ileus, inflammatory bowel disease (i.e. Crohn's disease, ulcerative colitis), and severe dehydration.
If the patient has experienced an allergic reaction, stop using this product and inform the doctor or pharmacist immediately.

Do not use laxative products when abdominal pain, nausea or vomiting is present unless directed by the doctor. Laxative products should not be used for a period longer than 1 week unless directed by the doctor. Long term use of stimulant laxatives should be avoided as it may lead to impaired function of the intestine, dependence of laxatives, dehydration and electrolyte imbalance. Prolonged excessive use or misuse of these products may also result in the development of atonic colon. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a serious condition. Discontinue use and consult the doctor. Note: For patients on a sodium-restricted diet, there is a very small amount of sodium in the sennosides.
In case of allergic symptoms, stop treatment and consult the doctor. Call the doctor if constipation does not improve or if it gets worse.
Pregnancy & lactation: If pregnant or nursing, seek the advice of the doctor before using the product.

If pregnant or nursing, seek the advice of the doctor before using the product.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. The patient may need to consult the doctor or pharmacist, if he/she notices any side effects.
The side effects listed as follows are classified by body system according to their incidence (common or uncommon). Common side effects have an incidence of ≥1% and uncommon effects have an incidence of <1%.
Gastrointestinal Disorders: Common: Abdominal pain. Uncommon: Feces discolored, nausea, rectal hemorrhage, vomiting, diarrhea.
Immune System Disorders: Uncommon: Urticaria, anaphylactic or anaphylactoid reaction, hypersensitivity.
Renal and Urinary Disorders: Uncommon: Chromaturia.
Reproductive System and Breast Disorders: Uncommon: Breast milk discoloration.
Skin and Subcutaneous Tissue Disorders: Uncommon: Erythematous rash, maculo-papular rash, perianal irritation, pruritus.
Due to the presence of chrysophanic acid in natural senna, sennoside-containing laxatives may cause discoloration of breast milk, urine, or feces. There is no pathologic significance to this discoloration. Urine discoloration (chromaturia), if present, may interfere with the interpretation of laboratory tests.
Reversible pigmentation of the colon, i.e., melanosis coli, may also result from prolonged use of senna containing preparations.

There are no known drug interactions with sennosides.

Store at temperatures not exceeding 30°C.

Laxatives, Purgatives

A06AB06 - senna glycosides ; Belongs to the class of contact laxatives.

Non-Rx