Roswin Dosage/Direction for Use

General Dosing Recommendations: Lipid-altering agents such as rosuvastatin should be used in conjunction with appropriate diet and exercise.
Individualize dose according to goal of therapy and response. Determine lipid levels within 2 to 4 weeks after initiating and/or titrating rosuvastatin therapy and adjust dosage accordingly. Dose adjustment can be made at 2 to 4 weeks intervals.
Adult Dosage Range: 5 to 40 mg/day, given as a single dose at any time of the day, with or without food.
Usual Starting Dose: 10 to 20 mg once a day.
The 40 mg dose is only recommended for patients with severe hypercholesterolemia at high cardiovascular risk (in particular those with familial hypercholesterolemia), who do not achieve their treatment goal using the 20 mg dose, and in whom routine follow-up will be performed. Physician supervision is recommended when the 40 mg dose is initiated (see Contraindications).

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Dosage in Asian Patients: Initial Dose: 5 mg once a day.
The 40 mg dose is contraindicated in these patients.
Dosage in the Elderly (>70 years old): Initial Dose: 5 mg once a day.
Dosage in Patients Taking Ciclosporin: Limit dose to 5 mg once a day.
Dosage in Patients Taking Gemfibrozil, Lopinavir/Ritonavir and Atazanavir/Ritonavir: Limit dose to 10 mg once a day.
Dosage in Patients with Renal Impairment: Mild to Moderate Renal Impairment: Usual dose range.
Moderate Renal Impairment: 5 mg once a day.
The 40 mg dose is contraindicated in these patients.
Severe Renal Impairment: All doses of rosuvastatin are contraindicated.
Dosage in Patients with Hepatic Impairment: Mild to Moderate Hepatic Impairment: Usual dose range.
Severe Hepatic Impairment: 10 mg once a day.
Dose above 10 mg once a day should be carefully considered because of increased rosuvastatin exposure.
Dosage in Patients with Predisposing Factors to Myopathy: Initial Dose: 5 mg once a day.
The 40 mg dose is contraindicated in some of these patients.