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Patients with known hypersensitivity to any component of the product.
Patients with active liver disease including unexplained, persistent elevations in serum transaminases and any serum transaminase elevation exceeding three times the upper limit of normal (ULN).
Patients with severe renal impairment (creatinine clearance <30 mL/min).
Patients with myopathy.
Women who are or may become pregnant.
Breastfeeding.
Rosuvastatin 40 mg is contraindicated in patients with predisposing factors for myopathy/rhabdomyolysis. Such factors include: Moderate renal impairment (creatinine clearance <60 mL/min); Hypothyroidism; Personal or family history of hereditary muscular disorders; Previous history of muscular toxicity with another HMG-CoA reductase inhibitor or fibrate; Alcohol abuse; Situations where an increase in plasma rosuvastatin levels may occur; Asian patients; Concomitant use of fibrates.
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