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The potential nephrotoxicity of cephalosporins may be increased in the presence of gentamicin and monitoring of kidney function is therefore recommended with this combination.
Furosemide and piretanide may potentiate the ototoxicity of gentamicin, and ethacrynic acid, which is ototoxic in its own right, should be avoided with gentamicin.
Ticarcillin has been shown to reduce the gentamicin activity in vivo and, if clinically indicated, should be given at different times from gentamicin.
Neuromuscular blockade and respiratory paralysis have occasionally been reported from administration of aminoglycosides to patients who have received curare-type muscle relaxants during anesthesia.
Bacteriostatic antibiotics may give an antagonistic interaction, but in some cases (e.g. with clindamycin and lincomycin) the disadvantage of antagonism may be outweighed by the addition of activity against anaerobic organisms.
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