Patients should be closely monitored for any anginal symptoms (e.g., chest pain), since treatment with RHEA cilostazol may increase pulse rate which could induce angina pectoris. [A significant increase in PRP (pressure rate product) was observed during long-term administration of RHEA cilostazol in a clinical study to evaluate the drug's efficacy in the prevention of recurrence of cerebral infarction. Also, angina pectoris was observed in some of the patients treated with RHEA cilostazol.] (See Careful Administration and Important Precautions under Precautions, Adverse Reactions, and Pharmacology: Clinical Studies under Actions.)
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