Pharmacology: Pharmacokinetics: Ramipril acts as a prodrug of the diacid ramiprilat, its active metabolite. Following oral administration at least 50 to 60% is absorbed. Ramipril is metabolized in the liver to ramiprilat; other metabolites are inactive. Peak plasma concentrations of ramiprilat are achieved 2 to 4 hours after an oral dose of ramipril. Ramiprilat is about 56% bound to plasma proteins. About 60% of an oral dose of ramipril of an oral dose of ramipril is excreted in the urine, the rest in the feces. The effective half-life for accumulation of ramipril is 13 to 17 hours following multiple doses of ramipril 5 to 10 mg, but it is much longer for doses of 1.25 to 2.5 mg daily. The clearance of ramiprilat is reduced in renal impairment.
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