Contraindicated in patients with pre-existing CNS depression or coma, bone marrow suppression, pheochromocytoma or prolactin-dependent tumor. It should be used with caution or not at all in patients with impaired liver, kidney, cardiovascular, cerebrovascular and respiratory function and in those with angle-closure glaucoma, history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Care is required in patients with epilepsy or history of seizure.
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