The usual initial dose of quetiapine is 25 mg twice a day (every 12 hours) on day one, 50 mg twice daily (every 12 hours) on day two, 100 mg twice daily (every 12 hours) on day three and 150 mg twice daily (every 12 hours) on day four. The dosage is then adjusted to a usual range of 300 mg to 450 mg daily given in 2 divided doses (every 12 hours), or as prescribed by the physician.