Prevaclav 457 Drug Interactions

Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, and estradiol has been noted. This effect may also occur with amoxicillin and therefore, with co-amoxiclav. Probenecid decreases the renal tubular secretion of amoxicillin but does not affect clavulanic acid excretion. Concurrent use with co-amoxiclav may result in increased and prolonged blood levels of amoxicillin but not for clavulanic acid. The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both medicines as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia presenting these patients. No information is available about the concurrent use of co-amoxiclav and alcohol. However, the ingestion of alcohol whilst being treated with the betalactam antibiotics latamoxef, cefoperazone and cefamandole has precipitated a disulfiram-like (antabuse) reaction in some patients. Therefore, the ingestion of alcohol should be avoided during and for several days after treatment with co-amoxiclav.