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Hypersensitivity Reactions: Skin rashes and urticaria have been reported. These are actions which may be controlled with antihistamines and if necessary, systemic corticosteroids. Rare cases of erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and an occasional case of exfoliative dermatitis have been reported in patients on penicillin therapy. Cross sensitivity with other beta-lactam antibiotics (e.g., cephalosporins), may occur.
Hepatic Effects: As with some other antibacterial agents, a few cases of transient hepatitis and cholestatic jaundice have been reported.
Haematologic Effects: Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia and agranulocytosis have been reported during therapy with penicillins.
Local Reactions: Phlebitis at the site of injection has also been reported.
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