Childn >6 yr (18-40 kg) 5 mL tid, may be increased up to 50 mg/kg daily in divided doses every 8 hr in severe infection, <12 mth 25 mg/kg daily eg, 7.5-kg child would require 2 mL tid.
May be taken with or without food: Add 64 mL of water & shake. Best taken at start of meal for better absorption.
Contraindications
History of hypersensitivity to β-lactams eg, penicillins or cephalosporins. Patients w/ previous history of co-amoxiclav associated jaundice/hepatic dysfunction.
Not to be used w/ drugs that delay peristalsis eg, opiates & diphenoxylate w/ atropine. Provide fluids, electrolytes & protein replacement therapy when indicated. Hepatic dysfunction. Contains aspartame; patients w/ phenylketonuria. Avoid use during pregnancy especially 1st trimester. Lactation.
Decrease in plasma conc of total conjugated estriol & estradiol. Increased incidence of rashes w/ allopurinol. May precipitate disulfiram-like (antabuse) reaction w/ alcohol. Amoxicillin: Decreased renal tubular secretion that may result in increased & prolonged blood levels w/ probenecid.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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