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Reports of acute toxicity and/or death following overdosage with glucocorticoids are rare. No antidote is available. Treatment is probably not indicated for reactions due to chronic poisoning unless the patient has a condition that would render a patient unusually susceptible to ill effects from corticosteroids. In this case symptomatic treatment should be instituted as necessary. Anaphylactic and hypersensitivity reactions may be treated with adrenaline, positive-pressure artificial respiration and aminophylline. The patient should be kept warm and quiet.
The biological half-life of Dexamethasone in plasma is about 190 minutes.
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