Penodex Drug Interactions

Aspirin should be used in conjunction with corticosteroids in hypoprothrombinemia.
The renal clearance of salicylates is increased by corticosteroids and therefore salicylate dosage should be reduced along with steroids withdrawal. As phenytoin, barbiturates, ephedrine, rifabutin, carbamazepine, rifampicin, and aminogluthetimide may enhance the metabolic clearance of corticosteroid, resulting in decreased blood levels and reduced physiological activity the dosage may have to be adjusted. These interactions may interfere with dexamethasone suppression tests which should be interpreted with caution during administration of these drugs.
False negative results in patients being treated with indomethacin have been reported.
The efficacy of coumarin anticoagulants may be changed by concurrent corticosteroid treatment. The prothrombin time should be checked frequently in patients who are receiving corticosteroids and coumarin anticoagulants at the same time in order to avoid spontaneous bleeding. The desired effects of hypoglycemic agents (including insulin), are antagonized by corticosteroids.
When corticosteroids are administered concomitantly with potassium-depleting diuretics, patients should be observed closely for development of hypokalemia.
Corticosteroids may affect the nitrobluetetrazolium test for bacterial infection and produce false-negative results.