Corticosteroid.
Use in certain endocrine and non-endocrine disorders responsive to corticosteroid therapy.
Systemic administration: Dexamethasone sodium phosphate Injection is recommended for systemic administration by intravenous or intramuscular injection when oral therapy is not feasible or desirable in the following conditions.
Endocrine disorders: Primary or secondary adrenocortical insufficiency: (hydrocortisone or cortisone is the first choice, but synthetic analogues may be used with mineralocorticoids where applicable and, in infancy, mineralocorticoid supplementation is particularly important.)
Non-endocrine disorders: Dexamethasone sodium phosphate may be used in the treatment of non-endocrine corticosteroid responsive conditions including: Allergy and anaphylaxis: Angioneurotic edema and anaphylaxis.
Gastro-intestinal: Crohn's disease and ulcerative colitis.
Infection (with appropriate chemotherapy): Miliary tuberculosis and endotoxic shock.
Neurological disorders: Raised intracranial pressure secondary to cerebral tumors and infantile spasms.
Respiratory: Bronchial asthma and aspiration pneumonitis.
Skin disorders: Toxic epidermal necrolysis.
Shock: Adjunctive treatment where high pharmacological doses are needed. Treatment is an adjunct to, and not a substitute for specific supportive measures the patient may require. Dexamethasone has been shown to be beneficial when used in the early treatment of shock, but it may not influence overall survival.
Local administration: Dexamethasone sodium phosphate Injection is suitable for intra-articular or soft-tissue injection as adjunctive therapy for short-term administration in: Soft-tissue disorders such as carpal tunnel syndrome and tenosynovitis.
Intra-articular disorders such as rheumatoid arthritis and osteoarthritis with an inflammatory component. Dexamethasone sodium phosphate injection may be injected intralesionally in selected skin disorders such as cystic acne vulgaris, localized lichen simplex, and keloids.
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