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The risk of Paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes. The absorption of Paracetamol may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when given with probenecid.
Colestyramine reduces the absorption of Paracetamol if given within 1 hour of Paracetamol.
Orphenadrine is an inhibitor of the cytochrome P450 isoenzymes CYP2B6 which is involved in the metabolism of buproprion to its major metabolites, should be used with caution in patients also receiving buproprion.
